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These studies further report that melatonin has significant abilities to block pro-inflammatory processes acting on cyclooxygenase (COX-2) and enhance programmed cell death (apoptosis) in aberrant cells [29,32], which would theoretically make it a desirable therapeutic in diseases of aging (“inflammaging”), such as cancer

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However, investigation of the charge effect on monoclonal antibodies conjugated with cytotoxic payloads remains elusive